What is PGT-M?

PGT-M is a specialized genetic test designed to detect known single-gene (monogenic) disorders in embryos created through IVF. Unlike PGT-A, which screens for chromosomal abnormalities, PGT-M specifically targets inherited conditions caused by gene variants passed down within families.

Each PGT-M test is customized to the couple’s unique genetic background. By identifying and selecting embryos free from the disease-causing gene variant, PGT-M greatly reduces the risk of having a child affected by the targeted genetic disorder.

Who is PGT-M for?

PGT-M may be recommended for:

• Couples who are carriers of the same gene disorder, e.g. Thalassaemia, Sickle Cell Disease, Lysosomal Storage Disorders, etc.
• Couples with a pregnancy history or child diagnosed with a single-gene disorder
• Individuals diagnosed with an autosomal dominant condition
• Women who are carriers of X-linked disorders

Benefits of PGT-M

• Reduces the risk of passing on inherited genetic disorders
• Enables selection of healthy embryos for transfer
• Provides couples with confidence and reassurance in family planning
• Supports the goal of having a healthy child while reducing emotional and medical challenges associated with genetic diseases