Other Tests
Comprehensive fetal screening and diagnostic solutions for early risk detection to support a healthy, informed pregnancy journey.
Prenatal screening and diagnostic services provide critical information about the health and development of a fetus during pregnancy. These tests help assess the risk of chromosomal conditions, structural anomalies, and inherited disorders—enabling early detection, timely intervention, and informed decision-making. Our offerings include non-invasive screening options, trimester-based risk assessments, and confirmatory diagnostic tests tailored to various stages of pregnancy.
ThalaCheck® Alpha (5 del & point mutations)
This test is designed to detect mutations in alpha-globin gene (HBA). Multiplex GAP-PCR is used to detect five large deletions in HBA which are double gene deletions (–SEA, –FIL, –THAI) and single gene deletion (-α3.7 and -α4.2). Sanger sequencing is used to detect point mutations, small deletions/insertions in HBA2 from Initiation codon (NG_000006.1:g.33776) to Poly A (NG_000006.1:g.34557) which include Hb Adana Cd59 (GGC->GAC), Hb Westmead Cd122 (CAC->CAG), Hb Quong Sze Cd125 (CTG->CCG), Hb Constant Spring Cd142 (TAA->CAA) and etc. Point mutations, small deletions/insertions in HBA1 and other large deletions are not included in this test
ThalaCheck® Alpha (5 del)
For the detection of 5 deletions in a-globin gene which includes (–SEA, –FIL, –THAI, -α3.7 and -α4.2) Note: Applicable to Add-on ThalaCheck® Alpha (Point mutations only) [TAT: 10 working days] as a subsequent test after receiving the ThalaCheck® Alpha (5 del only) test report
ThalaCheck® Alpha (point mutations) – Available as reflex test to ThalaCheck® Alpha (5 del)
This test is used to detect point mutations, small deletions/insertions in HBA2 from Initiation codon (NG_000006.1:g.33776) to Poly A (NG_000006.1:g.34557) which include Hb Adana Cd59 (GGC->GAC), Hb Westmead Cd122 (CAC->CAG), Hb Quong Sze Cd125 (CTG->CCG), Hb Constant Spring Cd142 (TAA->CAA) and etc using Sanger sequencing. Point mutations, small deletions/insertions in HBA1 and other large deletions are not included in this test.
ThalaCheck® Beta
This test is designed to detect mutations in the beta globin gene (HBB). Sanger sequencing is used to detect point mutations, small deletions/insertions in the HBB gene present from the 5’ untranslated region (NG_000007.3:g.70457) to Poly A (NG_000007.3:g.72131), including -88, -30, -29, -28, CAP+1, initiation codon, Cd5, Cd8/9, Cd14/15, Cd15, Cd17, Cd19, Cd26, Cd27/28, IVS1-1, IVS1-2, IVS1-5, Cd35, Cd41/42, Cd43, Cd71/72, IVS2-654, Poly A, and 619bp deletion. A multiplex GAP-PCR is used to detect a 45kb Filipino deletion. Other mutations present outside of the targeted genomic regions and untargeted large deletions are not covered by this test.
Sickle Cell (HbS) and Hemoglobin C (HbC)
For the detection of Sickle Cell (HbS) and Hemoglobin C (HbC) mutations in β-globin gene.
Spinal Muscular Atrophy (SMA) Testing
To detect copy number changes of exons 7 and 8 of SMN1 and SMN2 genes for patient diagnosis and carrier testing of spinal muscular atrophy by using Multiplex Ligation-Dependent Probe Amplification (MLPA).
DNA Paternity / Maternity Test
Comparison of DNA profiles of the Child and the Alleged Father or Alleged Mother using PCR-STR (Polymerase Chain Reaction-Short Tandem Repeat) method.
This test is NOT designed for legal proceedings.Â
Non-Invasive Paternity Test
Comparison of DNA profiles of the child and the alleged father using SNP (Single Nucleotide Polymorphism) typing with maternal plasma DNA sequencing (This test is not designed for legal proceedings). NOTE: This test is only applicable for singleton and twin pregnancy
The specimen will be tested by our qualified referral lab
